Polymer systems for radiopharmaceutical purposes

Specific advantageous physico-chemical and biological properties of polymers and biomimetic supramolecular polymer systems are extremely useful for the construction of polymer drug, gene and radionuclide delivery systems. This is especially true for external stimuli-responsive polymer systems that change their behavior depending on surrounding environment. The Supramolecular Polymer Systems group at the Institute of Macromolecular Chemistry CAS has long time experience with the construction of radionuclide, drug and non-proton MRI contrast agent delivery systems based on stimuli-responsive polymers devoted to especially cancer and other medical applications. Several examples will be presented in the lecture, namely i) novel hybrid thermoresponsive polysaccharide-graft-poly(2-oxazoline)s for immunoradiotherapy, ii) advanced pH-responsive polymer system for the intercalator-aimed delivery of Auger electron emitters and iii) reactive oxygen species- and thermoresponsive polymer theranostic system for 19F magnetic resonance imaging.